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class=\"wp-block-paragraph\">\u8fd9\u4e00\u7cfb\u5217\u5b9e\u9a8c\uff0c\u6700\u7ec8\u63ed\u5f00\u4e86\u5b8c\u6574\u771f\u76f8\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CGRP\u4e0d\u76f4\u63a5\u4fc3\u764c\uff0c\u800c\u662f\u901a\u8fc7\u6291\u5236\u4eba\u4f53\u6297\u80bf\u7624\u514d\u75ab\u4f53\u7cfb\uff0c\u62c6\u6389\u8eab\u4f53\u7684\u6297\u764c\u5c4f\u969c\uff0c\u95f4\u63a5\u5e2e\u80bf\u7624\u8086\u610f\u751f\u957f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e86\u89e3\u5438\u70df\u4e0eCGRP\u7684\u5173\u7cfb\uff0c\u91cd\u65b0\u8bfb\u61c2\u80ba\u817a\u764c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u6761\u673a\u5236\u4e5f\u5b8c\u7f8e\u89e3\u91ca\u4e86\u4e09\u4ef6\u4e8b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c\u4e00\uff0c\u4e3a\u4ec0\u4e48\u5438\u70df\u662f\u80ba\u764c\u7b2c\u4e00\u5927\u8bf1\u56e0\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9999\u70df\u6301\u7eed\u6fc0\u6d3b\u75db\u89c9\u795e\u7ecf\u5143\uff0c\u6e90\u6e90\u4e0d\u65ad\u63d0\u4f9b CGRP\uff0c\u7b49\u4e8e\u957f\u671f\u7ed9\u80bf\u7624\u63d0\u4f9b\u514d\u75ab\u63a9\u62a4\u3002\u8eab\u4f53\u7684\u6297\u764c\u90e8\u961f\u76f4\u63a5\u88ab\u524a\u5f31\uff0c\u764c\u7ec6\u80de\u81ea\u7136\u66f4\u5bb9\u6613\u5b9a\u5c45\u3001\u589e\u6b96\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c\u4e8c\uff0c\u786e\u8bca\u80ba\u764c\u540e\uff0c\u4e3a\u4ec0\u4e48\u5fc5\u987b\u7acb\u523b\u6212\u70df\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f88\u591a\u60a3\u8005\u89c9\u5f97\uff1a\u90fd\u5df2\u7ecf\u5f97\u4e86\u80ba\u764c\uff0c\u6212\u4e0d\u6212\u65e0\u6240\u8c13\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6070\u6070\u76f8\u53cd\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ee7\u7eed\u62bd\u70df = \u7ee7\u7eed\u6fc0\u6d3b\u75db\u89c9\u795e\u7ecf= \u6301\u7eed\u91ca\u653e CGRP = \u6301\u7eed\u538b\u5236\u514d\u75ab\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b49\u4e8e\u4e00\u8fb9\u6cbb\u7597\u6297\u764c\uff0c\u4e00\u8fb9\u4e3b\u52a8\u5e2e\u80bf\u7624\u8eb2\u907f\u514d\u75ab\u8ffd\u6740\uff0c\u6cbb\u7597\u6548\u679c\u5927\u6253\u6298\u6263\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6212\u70df\uff0c\u672c\u8d28\u4e0a\u5c31\u662f\u5207\u65ad\u8fd9\u6761 \u201c\u75db\u89c9\u795e\u7ecf\u5143\u2014CGRP\u2014 \u514d\u75ab\u6291\u5236\u201d \u901a\u8def\uff0c\u5e2e\u8eab\u4f53\u91cd\u65b0\u62ff\u56de\u514d\u75ab\u4e3b\u52a8\u6743\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c\u4e09\uff0c\u4e3a\u4ec0\u4e48\u201c\u4e8c\u624b\u70df\u201d\u4e5f\u4e0e\u80ba\u764c\u53d1\u75c5\u6709\u5173\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u867d\u7136\u4e0d\u5438\u70df\uff0c\u4f46\u662f\u201c\u4e8c\u624b\u70df\u201d\u5438\u8fdb\u7684\u70df\u96fe\uff0c\u540c\u6837\u53ef\u4ee5\u523a\u6fc0CGRP\u5206\u6ccc\uff0c\u540c\u6837\u4f1a\u524a\u5f31\u514d\u75ab\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u597d\u6d88\u606f\uff1a\u5168\u65b0\u6297\u764c\u601d\u8def\uff01CGRP\u6291\u5236\u5242\uff0c\u6709\u671b\u5e2e\u5438\u70df\u8005\u63d0\u5347\u514d\u75ab\u6cbb\u7597\u6548\u679c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bcf\u4e00\u76d2\u9999\u70df\u7684\u5305\u88c5\u4e0a\uff0c\u90fd\u9192\u76ee\u5370\u7740\u201c\u5438\u70df\u6709\u5bb3\u5065\u5eb7\u201d\uff0c\u53ef\u591a\u6570\u70df\u6c11\u65e9\u5df2\u9ebb\u6728\u3001\u89c6\u800c\u4e0d\u89c1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5982\u4eca\u5927\u91cf\u7814\u7a76\u5df2\u7ecf\u8bc1\u5b9e\uff1a\u5438\u70df\u4f1a\u6301\u7eed\u6fc0\u6d3b\u75db\u89c9\u795e\u7ecf\uff0c\u5347\u9ad8 CGRP \u6c34\u5e73\uff0c\u4e0d\u4ec5\u653e\u5927\u5168\u8eab\u75db\u611f\u3001\u8bf1\u53d1\u504f\u5934\u75db\uff0c\u8fd8\u4f1a\u538b\u5236\u673a\u4f53\u514d\u75ab\u3001\u52a9\u529b\u80bf\u7624\u751f\u957f\u3002\u53ef\u5728\u5c3c\u53e4\u4e01\u6210\u763e\u7684\u88f9\u631f\u4e0b\uff0c\u4e0d\u5c11\u4eba\u4f9d\u65e7\u6df1\u9677\u201c\u75db\u5e76\u5feb\u4e50\u7740\u201d \u7684\u6076\u6027\u5faa\u73af\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u597d\u5728\u79d1\u7814\u4ece\u4e0d\u6b62\u4e8e\u63ed\u793a\u98ce\u9669\uff0c\u6478\u6e05\u81f4\u75c5\u673a\u5236\uff0c\u5c31\u7b49\u4e8e\u627e\u5230\u4e86\u7834\u5c40\u65b9\u5411\u3002\u5bf9\u5e7f\u5927\u5438\u70df\u8005\uff0c\u5c24\u5176\u662f\u5438\u70df\u7684\u80ba\u764c\u60a3\u8005\u6765\u8bf4\uff0c\u8fd9\u5e94\u8be5\u7b97\u662f\u4e00\u4e2a\u503c\u5f97\u5173\u5fc3\u7684\u65b9\u5411\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0cCGRP\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u6216\u8bb8\u80fd\u6210\u4e3a\u5438\u70df\u8005\u6297\u764c\u7684\u65b0\u5e2e\u624b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u9879\u65b0\u53d1\u8868\u7684\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528\u7684\u836f\u7269\u662fOlcegepant\uff08\u7b80\u79f0OLC\uff09\uff0c\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u5b9e\u9a8c\u7ed9\u51fa\u4e86\u4eae\u773c\u7ed3\u679c\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u8fdb\u884c\u6297PD-1\u514d\u75ab\u6cbb\u7597\u524d\uff0c\u77ed\u671f\u4f7f\u7528OLC\u201c\u5b89\u629a\u201d\u8fc7\u5ea6\u6fc0\u6d3b\u7684\u75db\u89c9\u795e\u7ecf\uff0c\u5c31\u80fd\u663e\u8457\u63d0\u5347\u201c\u5438\u70df\u201d\u5c0f\u9f20\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u654f\u611f\u5ea6\uff0c\u589e\u5f3a\u6297\u764c\u6548\u679c\u3002\u540c\u65f6\u53d1\u73b0\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">OLC\u5904\u7406\u53ef\u589e\u52a0TLS\u6570\u91cf\uff0c\u518d\u6b21\u9a8c\u8bc1 \u201c\u963b\u65adCGRP\u201d= \u201c\u589e\u52a0TLS\u201d\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6e05\u9664\u5de8\u566c\u7ec6\u80de\u540e\uff0cOLC\u7684\u6291\u764c\u4f5c\u7528\u76f4\u63a5\u6d88\u5931\uff0c\u8bf4\u660eCGRP\u4e3b\u8981\u901a\u8fc7\u5de8\u566c\u7ec6\u80de\u4fc3\u8fdb\u80bf\u7624\u53d1\u5c55\uff1b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7b56\u7565\u4ec5\u5bf9\u201c\u5438\u70df\u201d\u5c0f\u9f20\u6709\u6548\uff0c\u5728\u201c\u4e0d\u5438\u70df\u201d\u5c0f\u9f20\u8eab\u4e0a\u51e0\u4e4e\u4e0d\u8d77\u4f5c\u7528\uff0c\u662f\u4e13\u4e3a\u5438\u70df\u4eba\u7fa4\u8bbe\u8ba1\u7684\u5e72\u9884\u601d\u8def\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cOLC\u539f\u672c\u662f\u5f00\u53d1\u7528\u4e8e\u504f\u5934\u75db\u6cbb\u7597\u3002\u5176II\u671f\u4e34\u5e8a\u6570\u636e\u4eae\u773c\uff0c\u5934\u75db\u7f13\u89e3\u7387\u8fbe66%\uff0c\u8fdc\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\u768427%\u3002\u53ef\u60dc\u5b83\u53ea\u80fd\u9759\u8109\u6ce8\u5c04\uff0c\u4f7f\u7528\u4e0d\u4fbf\uff0c\u6700\u7ec8\u672a\u80fd\u7ee7\u7eed\u5f00\u53d1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f46\u540c\u7c7b\u836f\u7269\u65e9\u5df2\u8fce\u6765\u7a81\u7834\uff1a\u76ee\u524d\u5df2\u67094\u6b3e\u53e3\u670dCGRP\u53d7\u4f53\u62ee\u6297\u5242\u5728\u7f8e\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u4e13\u95e8\u7528\u4e8e\u6cbb\u7597\u504f\u5934\u75db\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e4c\u5e03\u5409\u6cee\uff08Ubrogepant\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5229\u5179\u5409\u6cee\uff08Rimegepant\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u963f\u6258\u5409\u6cee\uff08Atogepant\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f50\u7c73\u5409\u6cee\uff08Zavegepant\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53ef\u4ee5\u9884\u89c1\uff0c\u5f88\u5feb\u5c31\u4f1a\u6709\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5c06\u8fd9\u7c7b\u53e3\u670d\u836f\u4e0e PD\u20111 \u514d\u75ab\u836f\u8054\u5408\uff0c\u7528\u4e8e\u80ba\u764c\u751a\u81f3\u66f4\u591a\u764c\u75c7\u7684\u6cbb\u7597\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f46\u5373\u4fbf\u672a\u6765\u65b0\u836f\u53ef\u671f\uff0c\u73b0\u9636\u6bb5\u5e94\u5bf9\u5438\u70df\u5e26\u6765\u7684\u80bf\u7624\u98ce\u9669\uff0c\u6212\u70df\u4f9d\u65e7\u662f\u6700\u5b89\u5168\u3001\u9ad8\u6548\u3001\u96f6\u6210\u672c\u7684\u6700\u4f18\u89e3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6212\u70df\uff0c\u4e0d\u662f\u4e3a\u96be\u81ea\u5df1\uff0c\u800c\u662f\u91dc\u5e95\u62bd\u85aa\uff0c\u65ad\u4e86\u80bf\u7624\u7684\u9760\u5c71\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6212\u70df\uff0c\u662f\u5728\u4e3a\u96be\u80bf\u7624\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Ho, Y.-H., et al., Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer. Cell.2026.<\/li>\n\n\n\n<li>Balood, M., et al., Nociceptor neurons affect cancer immunosurveillance. Nature, 2022. 611(7935): p. 405-412.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\uff08\u4f5c\u8005\uff1a\u5f20\u6d2a\u6d9b\uff0c\u7b14\u540d\u201c\u4e00\u8282\u751f\u59dc\u201d\uff0c\u8457\u6709\u79d1\u666e\u8bfb\u7269\uff1a\u300a\u5403\u4ec0\u4e48\u5462\uff1f\u2014\u2014\u820c\u5c16\u4e0a\u7684\u601d\u8003\u300b\uff0c\u300a\u5982\u679c\u820c\u5c16\u80fd\u601d\u8003\u300b\u3002\u53ef\u4ee5\u8c08\u6700\u524d\u6cbf\u7684\u533b\u5b66\u7814\u7a76\uff0c\u4e5f\u53ef\u4ee5\u8bb2\u6700\u901a\u4fd7\u7684\u6545\u4e8b\u3002\u672c\u6587\u4ec5\u4f5c\u4e3a\u533b\u5b66\u7814\u7a76\u8fdb\u5c55\u53ca\u5065\u5eb7\u4fdd\u5065\u5e38\u8bc6\u79d1\u666e\uff0c\u4e0d\u4f5c\u4e3a\u4efb\u4f55\u533b\u7597\u5efa\u8bae\u3002\u82e5\u6709\u4e0d\u9002\uff0c\u8bf7\u5c3d\u5feb\u5c31\u533b\uff0c\u9075\u533b\u5631\u5bf9\u75c7\u6cbb\u7597\uff09<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u539f\u6807\u9898\uff1a\u300a\u4f60\u4ee5\u4e3a\u62bd\u70df\u662f\u5728\u201c\u6b62\u75db\u201d\uff1f\u5927\u9519\u7279\u9519\uff01\u5b83\u6b63\u5728\u6084\u6084\u7ed9\u4f60\u7684\u764c\u7ec6\u80de\u201c\u677e\u7ed1\u201d\uff0c\u8ba9\u75bc\u75db\u7ffb\u500d\u2026\u2026\u300b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u533b\u5b66\u9662\u75c5\u7406\u53ca\u5b9e\u9a8c\u533b\u836f\u7cfb\u7814\u7a76\u526f\u6559\u6388\u5f20\u6d2a\u6d9b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/mp.weixin.qq.com\/s\/30Vme4l6xY1bQigmnUwnMQ\">https:\/\/mp.weixin.qq.com\/s\/30Vme4l6xY1bQigmnUwnMQ<\/a><\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>1 \u5c3c\u53e4\u4e01\u77ed\u6682\u6b62\u75db\u662f\u5047\u8c61\uff0c\u957f\u671f\u5438\u70df\u653e\u5927\u75db\u611f\u662f\u771f\u76f8 \u5927\u5bb6\u90fd\u77e5\u9053\uff0c\u5c3c\u53e4\u4e01\u672c\u8eab\u6709\u77ed\u6682\u7684\u9547\u75db\u4f5c\u7528\uff0c\u4e5f\u6b63\u56e0\u5982\u6b64\uff0c\u957f\u671f\u4ee5\u6765 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":489,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"aside","meta":{"_acf_changed":false,"footnotes":""},"categories":[10],"tags":[],"class_list":["post-284","post","type-post","status-publish","format-aside","has-post-thumbnail","hentry","category-science","post_format-post-format-aside"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.sipkt.com\/index.php?rest_route=\/wp\/v2\/posts\/284","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sipkt.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sipkt.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sipkt.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sipkt.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=284"}],"version-history":[{"count":0,"href":"https:\/\/www.sipkt.com\/index.php?rest_route=\/wp\/v2\/posts\/284\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sipkt.com\/index.php?rest_route=\/wp\/v2\/media\/489"}],"wp:attachment":[{"href":"https:\/\/www.sipkt.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=284"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sipkt.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=284"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sipkt.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}